Genetic association of apoE and apoCI gene polymorphisms with coronary heart disease / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 982-985, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-324976
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic association of apolipoprotein (apo) E and apoCI gene polymorphisms with coronary heart disease (CHD) in China.</p><p><b>METHODS</b>apoE genotypes were identified by multiplex amplification refractory mutation system (multi-ARMS) and the apoCI promoter polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 186 cases with CHD (age 65.0 +/- 10.5 years) and 350 controls (age 63.6 +/- 8.3 years). The haplotype frequencies were estimated.</p><p><b>RESULTS</b>The frequencies of apoE E4/3 genotype (26.9%) and epsilon4 (14.5%) in CHD group were significantly higher than that in the control group (12.6%, 7.0%), P <0.05. The significant difference was also found for the apoCI locus and the CHD group showed higher rate of both for the H2 allele and genotypes, carrying this allele. Estimation of the haplotype frequencies indicated that the association between the apoE-CI haplotype and CHD was significantly strong. The apoE-epsilon4/apoCI-H2 was estimated to be responsible for 9.86% of CHD.</p><p><b>CONCLUSION</b>When the subjects carrying both epsilon4 and H2 alleles, they would have higher risk of suffering from CHD than controls.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins C
/
Apolipoproteins E
/
Blood
/
Haplotypes
/
Polymorphism, Restriction Fragment Length
/
China
/
Polymerase Chain Reaction
/
Epidemiology
/
Risk Factors
/
Coronary Disease
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article
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