Association between high-risk human papillomavirus DNA load and cervical intraepithelial lesion / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 921-924, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-324993
ABSTRACT
<p><b>OBJECTIVE</b>To determine the association between viral load of high risk type human papillomavirus (HR-HPV) and stage of cervical intraepithelial neoplasia (CIN) lesion.</p><p><b>METHODS</b>Cervical exfoliated cells were collected from 1997 women aged 35-45 in a cross-sectional screening study. HPV DNA was detected by hybrid capture 2 (HC2) system, and viral load was measured by the ratios of relative light units compared to standard positive control (RLU/PC). Log10RLU/PC were categorized into four groups negative (< 0), low viral load (0 - 1.12), medium viral load (1.13 - 2.23), and high viral load (2.24 - 3.37). Cervical lesions were diagnosed by biopsies as normal, CIN 1, CIN 2-3, and squamous cervical cancer (SCC). Association between HR-HPV and CINs were evaluated by unconditional multinomial logistic regression.</p><p><b>RESULTS</b>100% (12/12) SCC, 97.3% (72/74) of CIN 2-3, 58.3% (74/127) of CIN 1, and 11.5% (205/1784) of normal women were positive for HPV DNA. The median log10RLUs for the positive women with SCC, CIN 2-3, CIN 1 and in normal women were 2.60, 2.32, 2.18 and 1.18 respectively. The odds ratio (OR) between low viral load of HPV DNA and CIN 1 was 3.8 (1.9 - 7.3) while between high viral load and CIN 2-3 was OR=865.9 (200.1 - 3738.0) which showed that higher viral load could increase the risk of cervical lesions (P <0.001).</p><p><b>CONCLUSION</b>Both cervical cancer and CINs were highly influenced by HR-HPV viral load.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Papillomaviridae
/
Virology
/
DNA, Viral
/
Logistic Models
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
China
/
Mass Screening
/
Epidemiology
/
Cross-Sectional Studies
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS