Clinical significance of tumor interstitial T lymphocyte subset activity in non-small-cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2456-2458, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325091
ABSTRACT
<p><b>OBJECTIVE</b>To study the relation of tumor interstitial T lymphocyte subset activity to the clinical staging of non-small-cell lung cancer (NSCLC) and the immune response.</p><p><b>METHODS</b>Immunohistochemical staining for CD4(+), CD8(+) and CD4(+)CD25(+) Foxp3(+) (regulatory T cells, Treg) T cells was performed on paraffin-embedded tissues from 60 NSCLC cases.</p><p><b>RESULTS</b>Compared to stage I/II NSCLC patients, patients in stage III/IV showed a significant decrease in the percentage of CD4(+) and CD4(+)/CD8(+) T cells (P<0.05) and an increase in CD8(+) and CD4(+)CD25(+) Foxp3(+) T cells (P<0.05). Treg cells were enriched in the tumor tissue as compared with those in the adjacent tissues.</p><p><b>CONCLUSIONS</b>The proportion of CD4(+)CD25(+) Foxp3(+) Treg cells is positively correlated to the clinical staging of NSCLC, in which T cell-mediated immune response is suppressed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
T-Lymphocyte Subsets
/
T-Lymphocytes, Regulatory
/
Carcinoma, Non-Small-Cell Lung
/
Allergy and Immunology
/
Lung
/
Lung Neoplasms
/
Neoplasm Staging
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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