Conversion to rapamycin in liver transpant recipients with renal insufficiency / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the efficacy of conversion from calcineurin-inhibitor (CNI) to rapamycin in liver recipients with CNI-associated renal insufficiency.</p><p><b>METHODS</b>This retrospective study examined the liver transplant recipients who had switched from CNI to rapamycin between January 2004 and June 2008 in the first affiliated hospital of Sun Yat-sen University. The data of renal function before and after the conversion were analyzed by Wilcoxon sum rank test, and rapamycin-related adverse effects were also observed.</p><p><b>RESULTS</b>Compared with that before conversion, the renal funtion 4 months after the conversion improved significantly (P<0.05). The blood lipid level 3 months after the conversion increased significantly (P<0.05) but were well controlled.</p><p><b>CONCLUSION</b>Rapamycin can be used safely as a good alternative in liver transplant recipients with CNI-related renal insufficiency.</p>