Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia / 中国实验血液学杂志

ABSTRACT

The mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia has been deeply researched in recent years. The roles of hematopoietic stem cells, some gene abnormalities including IKZF1, JAK, CRLF2 and CREBBP, as well as mutation of genes influencing drug resistance have been confirmed to related with relapse of disease. The microRNAs, gene expression profile of patient, microenvironment of bone marrow including bone marrow fibrosis, mesenchymal stem cells and matrix metalloprotease, also play an important role in the process of leukemia recurrence. This article reviewed the details mentioned above.