Research progress of mesenchymal stem cell-derived microvesicle / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 227-230, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-325179
ABSTRACT
Mesenchymal stem cell-derived microvesicle (MSC-MV) is a membrane secretory system which includes microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probably mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
MicroRNAs
/
Cell-Derived Microparticles
/
Mesenchymal Stem Cells
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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