Surveillance of CMV infection in allo-HSCT recipients and guidance on preemptive therapy by RQ-PCR / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 161-168, 2013.
Article
in English
| WPRIM
| ID: wpr-325192
ABSTRACT
In order to study the epidemiological characteristics of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients by means of plasma real time quantitative polymerase chain reaction (RQ-PCR), 141 adult patients undergoing allo-HSCT between January 2008 and June 2010 were serially monitored by RQ-PCR for detecting CMV and guiding the preemptive therapy followed up to 180 days post-HSCT. The results showed that the incidence of CMV infection and CMV pneumonia was 81.5% and 2.9% respectively, which mainly occurred within 2 months post-HSCT. Single-therapy with ganciclovir (GCV) for 63 patients or foscarnet 6 patients was performed for preemptive therapy. The total efficacy was 87.8%, and the response patterns were different. CMV infection was more frequent in female patients (P = 0.044), and those with aGVHD (P = 0.043), using ATG or basiliximab in conditioning regimens (P = 0.049), as well as earlier in patients using ATG or basiliximab or those with aGVHD (P = 0.007; P = 0.000). The aGVHD, maximum load, positive times of CMV-DNA detection and therapy duration all correlated with the efficacy (P < 0.05). It is concluded that the incidence of CMV infection is still high after HSCT. Plasma RQ-PCR assay for CMV-DNA shows a strong correlation with the clinical outcome of CMV infection, which is useful and suitable for management of CMV infection in HSCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Transplantation, Homologous
/
Polymerase Chain Reaction
/
Retrospective Studies
/
Cytomegalovirus Infections
/
Hematopoietic Stem Cell Transplantation
/
Cytomegalovirus
/
Therapeutic Uses
/
Diagnosis
/
Drug Therapy
Type of study:
Diagnostic study
/
Practice guideline
/
Observational study
/
Screening study
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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