Expression of MCL-1 and microRNA-29a in extranodal NK/T-cell lymphoma tissue / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 95-98, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-325205
ABSTRACT
This study was aimed to explore the expression level and correlation of MCL-1 and miR-29a in extranodal NK/T-cell lymphoma (ENKTCL) tissue. Maxvision immunohistochemistry technique and real time fluorescent quantitative PCR were used to detect the expression level of MCL-1 and miR-29a in tissue of 20 patients with ENKTCL and 10 patients with proliferative lymphadenitis, respectively. The results showed that the expression of MCL-1 protein were higher in patients with ENKTCL than that in patients with proliferative lymphadenitis, but there were no significant correlation between MCL-1 overexpression and age, sex, Ann Arbor stage and International Prognostic Index (IPI), respectively. Correlation analysis indicated that there was significant negative correlation between miR-29a expression and MCL-1 expression (r = -0.59, P = 0.016). It is concluded that miR-29a may target MCL-1 gene, regulate its expression, then participate in tumorigenesis and development of ENKTCL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Gene Expression Regulation, Neoplastic
/
MicroRNAs
/
Lymphoma, Extranodal NK-T-Cell
/
Myeloid Cell Leukemia Sequence 1 Protein
/
Genetics
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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