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Molecular mechanism of RhDel phenotype in blood donation population of Chinese Harbin area / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1478-1481, 2012.
Article in Chinese | WPRIM | ID: wpr-325235
ABSTRACT
This study was aimed to explore the molecular mechanism of RhDel phenotype expression in blood donors of Chinese Harbin area. Three hundred and seventy-four RhD negative donors confirmed by indirect antiglobulin test were detected by using serological and molecular methods for red blood cell RhD blood group genotyping and RH gene variant detection. And the other special samples of undetermined RhD genotype were sequenced. The results showed that 62 cases of Del type were detected in 374 negative blood donors' samples, accounting for 16.6%, among them there were 61 cases of RHD1227A, and 1 case of rare RHD Del (cde) 1 allele was found. Sequencing analysis indicated that RHD711DelC allele existed in 11 cases. In addition, the new mutant alleles were found in 3 samples. It is concluded that RHD1227A allele is generally carried allele in Del phenotype population of Chinese Harbin area and is an important genetic marker in Del phenotype individual.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Rh-Hr Blood-Group System / Blood Donors / Base Sequence / China / Exons / Asian People / Alleles / Genetics / Genotype Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Journal of Experimental Hematology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rh-Hr Blood-Group System / Blood Donors / Base Sequence / China / Exons / Asian People / Alleles / Genetics / Genotype Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Journal of Experimental Hematology Year: 2012 Type: Article