Frequency and linkage disequilibrium of specific HLA-DR and HLA-DQ genes in Chinese Han population / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1463-1468, 2012.
Article
in Zh
| WPRIM
| ID: wpr-325238
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the distribution feature of HLA-DR/DQ gene linkage disequilibrium in Chinese Han population and to improve the accuracy of HLA matching results. Genotyping of HLA-DR and HLA-DQ gene locus was performed using PCR-SSP typing in Chinese Han population receiving kidney transplantation. The results showed that there were 29 new linkage combinations in 1799 patients, in which DR13-DQ5, DR11-DQ8 and DR8-DQ8 were discovered for 11, 8 and 7 times respectively while DR9-DQ8, DR12-DQ6 and DR14-DQ4 were both discovered for 6 times. The linkage disequilibrium parameters of these haplotypes were negative, showing that these linkages were uncommon. It is concluded that this study not only enriches the classical HLA-DR/DQ linkage combinations, but also indicates the national relevance of combination distribution, and it has great importance in improving the accuracy of HLA matching experiments and reducing unnecessary repeated work.
Full text:
1
Index:
WPRIM
Main subject:
Haplotypes
/
HLA-DQ Antigens
/
HLA-DR Antigens
/
Linkage Disequilibrium
/
Kidney Transplantation
/
Asian People
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Adult
/
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2012
Type:
Article