Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in rabbits / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 343-346, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-325348
ABSTRACT
<p><b>OBJECTIVE</b>To compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .</p><p><b>METHODS</b>Sixty-six New Zealand white rabbits were divided into seven groups control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.</p><p><b>RESULTS</b>The positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.</p><p><b>CONCLUSIONS</b>The method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sinusitis
/
Chronic Disease
/
Disease Models, Animal
/
Microbiology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2005
Type:
Article
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