Design and implementation of DB sequence optimization software / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1032-1035, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-325430
ABSTRACT
TIR (Translation Initiation Region) efficiency is very important in prokaryotic expression. The TIR's efficiency is highly dependent on SD (Shine-Dalgarno) sequence, distance between SD sequence and start codon, DB (Downstream Box) sequence, TIR's second structure, codon adaptation and so on. In this paper, we designed and implemented the software to optimize DB sequence and 5' rare codons. It generated some optimization sequences by analyzing the target sequence and comparing it with 16S RNA. And the optimization sequences is sorting by number of base pairing, location of base pairing and codon adaptation. We drew up the algorithm and the core of code in this paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Biosynthesis
/
Programming Languages
/
Software
/
Codon
/
Base Sequence
/
Genetics
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2006
Type:
Article
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