Expression of peroxiredoxin III in cervical lesions / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 443-445, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325517
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression feature of peroxiredoxin III in cervical lesions and to further understand the mechanism for cervical cancer development/progression.</p><p><b>METHODS</b>Expression of peroxiredoxin III was immunohistochemically detected in cervical cancer. In addition, cervical epithelia were transfected with recombinant adeno-associated virus vector containing human papillomavirus 16 E6/E7 and peroxiredoxin III expression was detected by quantitative real time PCR and Western blotting.</p><p><b>RESULTS</b>Peroxiredoxin III was significantly up-regulated in cervical cancer tissues. Nevertheless, expression of peroxiredoxin III remained unchanged in cervical epithelial cells after transfection.</p><p><b>CONCLUSION</b>It seems that Prx III is not related to cervical cancer initiation. Up-regulation of peroxiredoxin III in cervical cancer might be an active response to oxidative stress in malignant cells, which protects against oxidatiton-induced apoptosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Repressor Proteins
/
Virology
/
Gene Expression Regulation, Neoplastic
/
Up-Regulation
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Oncogene Proteins, Viral
/
Human papillomavirus 16
/
Papillomavirus E7 Proteins
/
Peroxiredoxins
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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