Detection of peripheral blood HBV-LHBs transactivation function and its relationship with anti-viral efficacy / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 375-377, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325537
ABSTRACT
<p><b>OBJECTIVE</b>Explore the serum of patients with CHB of HBV large envelope protein (HBV-LHBs) trans-activation function and antiviral therapy effect relationship.</p><p><b>METHODS</b>60 cases of anti-viral treatment of patients with chronic hepatitis B to take every 3 months HBVDNA, HBV-LHBs, as well as detection of hepatitis B immune markers to observe the changes in indexes.</p><p><b>RESULTS</b>Income group 60 cases of anti-virus group HBVDNA with HBV-LHBs have a higher detection rate of the consistency of the results found no statistical significance (P > 0.05), HBV-LHBs-positive rate and positive rate of HBeAg differences (chi2 = 4.08, P < 0.05). After 24 months of antiviral therapy HBV-LHBs expression always HBVDNA in 29 cases of which occurred 24 months after the negative reaction of the 20 cases, continuous positive were seven cases of non-negative. 60 cases of patients 24 months found no HBsAg seroconversion, four cases of emergence of HBeAg seroconversion.</p><p><b>CONCLUSION</b>(1) detection of serum HBV-LHBs to reflect the hepatitis B virus replication with HBVDNA good correlation. (2) anti-viral treatment of dynamic observation of the process of HBV-LHBs expression can predict the effectiveness of anti-viral therapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Physiology
/
Virology
/
Virus Activation
/
Blood
/
DNA, Viral
/
Viral Envelope Proteins
/
Hepatitis B virus
/
Treatment Outcome
/
Therapeutic Uses
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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