Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 364-366, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325540
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.</p><p><b>METHODS</b>26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.</p><p><b>RESULTS</b>The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.</p><p><b>CONCLUSION</b>HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Polymorphism, Genetic
/
Virology
/
Severity of Illness Index
/
HLA-DR Antigens
/
Case-Control Studies
/
Hepatitis B virus
/
Hepatitis B, Chronic
/
HLA-DRB1 Chains
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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