Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 302-303, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325560
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.</p><p><b>METHODS</b>HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.</p><p><b>RESULTS</b>The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.</p><p><b>CONCLUSION</b>HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HLA-DR Antigens
/
Hepatitis B, Chronic
/
Alleles
/
HLA-DRB1 Chains
/
Genetics
/
Liver Cirrhosis
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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