The significance of HPV-DNA genotyping assays in the ASC / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 296-298, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325562
ABSTRACT
<p><b>OBJECTIVE</b>To disscuss different outcomes of ASC-UC and ASC-H, two subtypes of ASC, and the significance of HPV-DNA genotyping assays in these two subtypes.</p><p><b>METHODS</b>We reviewed and analyzed colposcopic and biopsy results of 1256 cases of ASC between Jan. 2005 to Dec. 2007, of which 580 cases have results of HPV-DNA genotyping assays.</p><p><b>RESULTS</b>In 1256 ASC cases, ASC-US and ASC-H cases account for 90.1% and 9.9% respectively, CIN2 and higher levels diagnosed via colposcopy and cervical biopsy are 8.5% and 24.2% respectively (P = 0.000). In ASC-US cases, the infection rate of HPV-DNA high risk types is 67.2%, there is statistic significance among different HPV-DNA results and biopsy pathology (P = 0.000). In ASC-H cases, the infection rate of HPV-DNA high risk types is 47.3%, there is no statistic significance among them (P = 0.054).</p><p><b>CONCLUSION</b>The clinical outcomes of ASC-US and ASC-H are different, we should distinguish and treat. HPV-DNA genotyping assay is available in ASC-US triage, but Colposcopy is proposed for all ASC-H patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
Uterine Cervical Neoplasms
/
Neoplasms, Squamous Cell
/
Papillomavirus Infections
/
Alphapapillomavirus
/
Genetics
/
Genotype
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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