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Expression and significance of liver X receptor-alpha in nonalcoholic fatty liver disease in rats / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 265-268, 2009.
Article in Chinese | WPRIM | ID: wpr-325571
ABSTRACT
<p><b>OBJECTIVE</b>Preparing rat model of non-alcoholic fatty liver disease by fat-rich diet to observe the expression and the role of LXR-alpha in rat nonalcoholic fatty liver disease.</p><p><b>METHODS</b>Thirty-six SD rats were randonmized into basic diet-control group and high-fat diet group. Each of the two groups was subdivided into 3 subgroups (4, 8, 12 weeks). Changes in animal weight, liver exponent and the level of TG and TC in serum and liver were observed dynamically. Meanwhile,the expression of hepatocyte LXR-alpha and SREBP-1c were assayed by Reverse transcript-polymerase chain reaction at 4, 8, 12 weeks. The level of steatosis was observed under light microscope after haematoxylon-eosin (HE) staening.</p><p><b>RESULTS</b>Compared with control group, body weight, liver exponent, TG and Tc in serum and liver were increased dynamically in model groups. Compared with control group, the mRNA of LXR-a and SREBP-1c were obviously increased dynamically in model groups (P < 0.05) .</p><p><b>CONCLUSION</b>The increase of LXR-alpha and SREBP-1c in liver may be concered with energy disorder and closely associated with the activity of inflammation and the severity of the liver damage in NAFLD rats.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Random Allocation / Rats, Sprague-Dawley / Disease Models, Animal / Sterol Regulatory Element Binding Protein 1 / Fatty Liver / Orphan Nuclear Receptors / Liver X Receptors / Genetics / Metabolism Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Random Allocation / Rats, Sprague-Dawley / Disease Models, Animal / Sterol Regulatory Element Binding Protein 1 / Fatty Liver / Orphan Nuclear Receptors / Liver X Receptors / Genetics / Metabolism Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2009 Type: Article