The immunological effects of three doses of a live attenuated hepatitis A vaccine (H2 strain) in 8 years / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 180-181, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-325598
ABSTRACT
<p><b>OBJECTIVE</b>To observe the immunological effects of three doses of H2 strain live attenuated hepatitis A vaccine 8 years after the administration and to compare with that of one dose of the vaccine.</p><p><b>METHODS</b>In a country area, 110 children of 1 to 7 years old susceptible to HAV were screened and administered with one dose of the vaccine, as group B; Group A were 42 children from one of the villages and administered with 3 doses of the vaccine according to 0, 2, 6 month schedule. Blood samples were taken for the children 1, 2, 6, 7, 8, 12, 24, 36 and 96 months after the administrations respectively and detected for anti-HAV antibody.</p><p><b>RESULTS</b>For group B, the sero conversion rate of anti-HAV and GMC reached peak at 92.2% and 126.2 mIU/ml respectively, and then, began to drop with time; For group A, after 2 dose of the vaccine, the sero-conversion rate reached 100%, and the GMC reached peak of 2 739 mIU/ml one month after the third dose at 7 months. So that, group A has a better short-term immunological effects than that of group B. During 36 through 96 months, the anti-HAV positive rate in group B was 75%-71% and 80-89 mIU/ml respectively, and comparatively in group A were 100% and 918.2-480.6 mIU/ml respectively. The differences between group A and B were significantly important.</p><p><b>CONCLUSION</b>A 3-dose schedule administration of H2 strain live attenuated hepatitis A vaccine has better immunological effects than 1-dose schedule in 8years and further observations are needed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Vaccines, Attenuated
/
Immunization Schedule
/
Immunization, Secondary
/
Hepatitis A Vaccines
/
Hepatitis A Antibodies
/
Allergy and Immunology
/
Hepatitis A
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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