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Influence of apolipoprotein E and its receptors on cerebral amyloid precursor protein metabolism following traumatic brain injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology ; (6): 183-187, 2012.
Article in English | WPRIM | ID: wpr-325798
ABSTRACT
Traumatic brain injury (TBI) is the leading cause of mortality and disability among young individuals in our society, and globally the incidence of TBI is rising sharply. Mounting evidence has indicated that apolipoprotein E (apoE protein; APOE gene) genotype influences the outcome after TBI. The proposed mechanism by which APOE affects the clinicopathological consequences of TBI is multifactorial and includes amyloid deposition, disruption of lipid distribution, dysfunction of mitochondrial energy production, oxidative stress and increases intracellular calcium in response to injury. This paper reviews the current state of knowledge regarding the influence of apoE and its receptors on cerebral amyloid beta-protein precursor metabolism following TBI.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Apolipoproteins E / Brain Injuries / Amyloid beta-Peptides / Metabolism Limits: Humans Language: English Journal: Chinese Journal of Traumatology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Apolipoproteins E / Brain Injuries / Amyloid beta-Peptides / Metabolism Limits: Humans Language: English Journal: Chinese Journal of Traumatology Year: 2012 Type: Article