The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 357-360, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-326360
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC).</p><p><b>METHOD</b>The expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC.</p><p><b>RESULTS</b>Absent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05).</p><p><b>CONCLUSIONS</b>Absent/reduced FHIT and WWOX expression is associated with poor prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Pathology
/
Prognosis
/
Acid Anhydride Hydrolases
/
Carcinoma, Hepatocellular
/
Gene Expression Profiling
/
Tumor Suppressor Proteins
/
WW Domain-Containing Oxidoreductase
/
Genetics
/
Liver Neoplasms
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2010
Type:
Article
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