Distributional characteristics of acylation stimulating protein gene 301T > C polymorphism and association with serum triglyceride in Han and Uighur residents in Xinjiang / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 929-932, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-326390
ABSTRACT
<p><b>OBJECTIVE</b>To explore the distributional characteristics of acylation stimulating protein (ASP) gene polymorphism and the association with serum lipid level of Chinese Han and Uighur residents in Xinjiang.</p><p><b>METHOD</b>Genotypes of the ASP gene 301T > C polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 527 Uighur and 407 Han residents.</p><p><b>RESULTS</b>The frequencies of TT, TC and CC genotype of ASP gene 301T > C were 74.9%, 21.3% and 3.6% in Han group and 47.6, 40.2% and 12.1% in Uighur group (P < 0.05). Serum triglyceride level was significantly higher in C allele carrier (TC + CC genotype) than in TT genotype carrier of both Han and Uighur individuals. After adjusting for age, gender, smoking, drinking, BMI and serum total cholesterol, logistic regression analyses revealed that individuals carrying C allele (TC + CC genotype) faced an increased risk of increased serum triglyceride level than individuals carrying TT genotype in both Han and Uighur individuals (OR = 3.31, 95%CI 1.31 - 8.36 in Uighur group; OR = 3.98, 95%CI 1.81 - 8.74 in Han group).</p><p><b>CONCLUSION</b>There is a significant difference on mutational frequencies of the ASP gene 301T > C polymorphism between Uighur and Han residents in Xinjiang and C allele carriers face an increased risk for hypertriglyceridemia in both Uighur and Han residents in Xinjiang.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Blood
/
Complement C3
/
Ethnicity
/
Polymorphism, Single Nucleotide
/
Intercellular Signaling Peptides and Proteins
/
Alleles
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2012
Type:
Article
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