Analysis of the risk factors of patients with acute coronary syndrome suffering hemorrhage during hospitalization / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 902-907, 2012.
Article
in Zh
| WPRIM
| ID: wpr-326395
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the risk factors related to in-hospital bleeding for patients with acute coronary syndrome (ACS).</p><p><b>METHODS</b>Clinical and therapeutic data of 3807 patients who were registered with acute coronary syndrome in SINO-GRACE in China from March 2001 to December 2007 were reviewed. A total of 57 patients were grouped to bleeding group and 234 out of the remaining 3750 patients without bleeding were randomly chosen and served as non-bleeding group. Hemorrhage-related factors were screened and compared between the two groups. Unitary logistic regression analysis was performed to detect the possible factors related to hemorrhage. Factors with P < 0.1 were further analyzed by stepwise regression method and multivariate conditional logistic regression analyses.</p><p><b>RESULTS</b>(1) Age, history of coronary artery bypass graft (CABG), previous hemorrhage, renal failure and heart failure as well incidence of acute coronary syndrome were significantly higher in bleeding group than in non-bleeding group (all P ≤ 0.05). Patients were more often treated with clopidogrel and glycoprotein (GP) IIb/IIIa receptor antagonist in bleeding group than in non-bleeding group. (2) Single factor logistic regression analysis showed that age > 70 years, history of previous bleeding, renal failure, heart failure, clopidogrel and GP IIb/IIIa receptor antagonists use, non-ST-segment elevation myocardial infarction, inferior wall, lateral myocardial infarction, CABG were risk factors for bleeding (all P < 0.05). (3) Multivariate logistic regression analysis showed that history of renal failure (OR = 19.77, 95%CI 4.38 - 89.18, P < 0.01) and clopidogrel (OR = 19.77, 95%CI 4.38 - 89.18, P < 0.01) and GPIIb/IIIa receptor antagonist (OR = 343.57, 95%CI 40.39 - 999.99, P < 0.01) use were the independent risk factors for bleeding.</p><p><b>CONCLUSION</b>Our results show that renal failure history and clopidogrel and GPIIb/IIIa receptor antagonist use are independent risk factors for in-hospital bleeding in patients with acute coronary syndrome.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Ticlopidine
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Logistic Models
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Incidence
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Risk Factors
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Age of Onset
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Platelet Glycoprotein GPIIb-IIIa Complex
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Therapeutic Uses
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Renal Insufficiency
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Acute Coronary Syndrome
Type of study:
Etiology_studies
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2012
Type:
Article