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Analysis of factors related to recurrence after local excision for low rectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 36-39, 2009.
Article in Chinese | WPRIM | ID: wpr-326562
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the factors predicting recurrence after local excision for low rectal cancer.</p><p><b>METHOD</b>Medical records and follow-up histories of 97 patients undergone local excision of adenocarcinoma of the rectum between April, 1975 and April, 2005 in Cancer Hospital of the Chinese Academy of Medical Sciences were reviewed retrospectively.</p><p><b>RESULTS</b>Postoperative pathologic examination revealed 28 pTis cases, 48 pT(1) cases, and 21 pT(2) cases. Eighty-nine patients underwent transanal excision, 7 transsacral excision, and 1 transvaginal excision. Twenty-two(45.8%) patients with T(1) tumors and 14(66.7%) patients with T(2) tumors were treated with postoperative radiotherapy with or without 5-fluorouracil. Seventeen(17.5%) patients presented recurrence, including 13 local recurrence, 2 local and distant recurrence, and 2 distant recurrence. The local recurrence rate was 15.5%. Median time to relapse was 27 months(range 4-73). The incidence of local recurrence were 7.1%, 12.5%, and 33.3% for patients with pTis, pT(1), and pT(2)(P=0.031) respectively. The local recurrence rate was 10.5%, 13.7%, and 3/5 for patients with pedunculated, sessile, and ulcerative carcinoma(P=0.017). The local recurrence of patients with T(2) tumors treated via local excision with or without chemoradiotherapy was 21.4%(3/14) and 4/7, but the difference was no significance(P=0.127). All the 15 patients with local recurrence underwent salvage resection, and the 5-year survival rate after salvage surgery was 59.6%.</p><p><b>CONCLUSIONS</b>Higher rates of recurrence are seen in patients with T(2) tumors and ulcerative carcinoma. Chemoradiotherapy or radical surgery should be chosen for T(2) tumors following local excision. Salvage resection should be considered after local recurrence.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Rectal Neoplasms / General Surgery / Retrospective Studies / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Rectal Neoplasms / General Surgery / Retrospective Studies / Neoplasm Recurrence, Local / Neoplasm Staging Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2009 Type: Article