Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 431-434, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-326730
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis.</p><p><b>METHODS</b>Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer.</p><p><b>RESULTS</b>JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur.</p><p><b>CONCLUSION</b>JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Pharmacology
/
Biomechanical Phenomena
/
Drugs, Chinese Herbal
/
Ovariectomy
/
Random Allocation
/
Absorptiometry, Photon
/
Bone Density
/
Rats, Sprague-Dawley
/
Therapeutic Uses
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2004
Type:
Article
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