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Proteinuria in a Boy with Infectious Mononucleosis, C1q Nephropathy, and Dent's Disease
Journal of Korean Medical Science ; : 928-931, 2007.
Article in English | WPRIM | ID: wpr-32679
ABSTRACT
C1q nephropathy is a proliferative glomerulopathy with extensive mesangial deposition of C1q. A three-year old boy presented with a nephrotic-range proteinuria during an acute phase of Epstein-Barr virus (EBV) infection, and he had a family history of Dent's disease. The renal biopsy findings were compatible with C1q nephropathy. However, EBV in situ hybridization was negative. The CLCN5 gene analysis revealed an R637X hemizygous mutation, which was the same as that detected in his maternal cousin, the proband of the family. The causal relationship between EBV infection and C1q nephropathy remains to be determined. Moreover, the effects of underlying Dent's disease in the process of C1q nephropathy has to be considered.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Proteinuria / Biopsy / Membrane Glycoproteins / Receptors, Complement / Treatment Outcome / In Situ Hybridization / Epstein-Barr Virus Infections / Glomerulonephritis / Infectious Mononucleosis / Kidney Diseases Limits: Child, preschool / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Proteinuria / Biopsy / Membrane Glycoproteins / Receptors, Complement / Treatment Outcome / In Situ Hybridization / Epstein-Barr Virus Infections / Glomerulonephritis / Infectious Mononucleosis / Kidney Diseases Limits: Child, preschool / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2007 Type: Article