Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 575-578, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326887
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.</p><p><b>METHODS</b>Choronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.</p><p><b>RESULTS</b>The rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregnant female seemed to be related with spontaneous abortion(P<0.01).</p><p><b>CONCLUSION</b>Chorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importance. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Risk Factors
/
Chorionic Villi
/
Chromosome Aberrations
/
Abortion, Missed
/
Genetics
/
Karyotyping
/
Metabolism
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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