Association of the IL-6 gene 634C/G polymorphism with susceptibility to endometriosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 555-558, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326892
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of interleukin 6 gene (IL-6) promoter region 634C/G (rs1800796) single nucleotide polymorphism (SNP) with the genetic susceptibility to endometriosis (Ems) in south Han Chinese women.</p><p><b>METHODS</b>A case-control study was performed in 432 Ems patients and 499 control women to evaluate the SNP of IL-6 634C/G by using a fluorescent quantitative PCR-based high resolution melting (HRM) method.</p><p><b>RESULTS</b>There were statistical significances in the IL-6 634C/G alleles, whether or not to carry allele G and genotype distributions between Ems patients and control women (P=0.032, 0.014 and 0.045, respectively). Allele C enhanced the risk of Ems 1.057 times while allele G reduced the risk of Ems 0.835 time. Carrying allele G reduced the risk of Ems 0.822 time, whereas not carrying allele G enhanced the risk of Ems 1.143 times. Compared with genotype CC, the risk of Ems with genotype CG reduced 0.704 time (95% CI 0.533-0.931). There was no significant difference in whether or not carrying allele G distribution between Ems patients and control women (P=0.729).</p><p><b>CONCLUSION</b>The present study demonstrated significant association between the SNP of IL-6 634C/G and genetic susceptibility to Ems in south Han Chinese women.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Interleukin-6
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Endometriosis
/
Alleles
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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