A family-based association study of FXYD6 gene polymorphisms and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 539-542, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326896
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population.</p><p><b>METHODS</b>Six SNPs (rs10790212, rs11544201, rs555577, rs1815774, rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families, and transmission disequilibrium test (TDT) was performed.</p><p><b>RESULTS</b>SNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P<0.05). Furthermore, significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P<0.05).</p><p><b>CONCLUSION</b>FXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Haplotypes
/
Linkage Disequilibrium
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
Genetics
/
Ion Channels
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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