Clinical and laboratory investigation of patients with hematologic malignancies harboring der(1;7)(q10;p10) / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 441-445, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326914
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical and laboratory characteristics of patients with various hematological malignancies harboring der(1;7)(q10;p10).</p><p><b>METHODS</b>Bone marrow samples were collected and undergone short-time unstimulated culture and R-banding, and karyotyped by conventional cytogenetic assay (CCA). Megalokaryocytes were detected by streptavidin-AKP (SAP). Retrospective analyses including the clinical and laboratory data were performed.</p><p><b>RESULTS</b>Nineteen of the 21 patients were male. Most of the patients are of older age. Thirteen cases (61.9%) were der(1;7)(q10;p10) without additional aberrations, 8(38.1%) patients had additional aberrations. Sixteen out of the 18 cases (88.9%) who underwent SAP analysis had diminutive megalokaryocyte, and lymphoid megalokaryocyte was found in 10 cases (55.6%). The der(1;7) patients manifested poor response to treatment.</p><p><b>CONCLUSION</b>The der(1;7) patients demonstrated distinct male predominance, older age at diagnosis, and some clinically distinctive features. These patients showed poor prognosis. The cytogenetic abnormality, i.e., der(1;7)(q10;p10), can be used as a prognostic indicator.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Therapeutics
/
Translocation, Genetic
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 7
/
Treatment Outcome
/
Hematologic Neoplasms
/
Genetics
/
Laboratories
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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