Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 313-317, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326939
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association between single nucleotide polymorphisms (SNPs) of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and susceptibility to cervical cancer.</p><p><b>METHODS</b>One hundred patients and 100 healthy controls from Hubei province were genotyped for 20 polymorphic loci using Sequenom.</p><p><b>RESULTS</b>The frequency of rs11571316 G allele and rs5742909 T allele, which are localized in the promoter region, and rs11571319 A allele, which is downstream of the gene, were significantly higher in patients than in controls. Luciferase assay showed that, as the previously reported rs5742909 T allele, rs11571316 G allele could significantly increase the expression of the reporter gene.</p><p><b>CONCLUSION</b>SNPs in the promoter region of (CTLA4) gene might increase the susceptibility to cervical cancer by increasing (CTLA4) gene expression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antigens, CD
/
Case-Control Studies
/
Gene Expression Regulation, Neoplastic
/
Uterine Cervical Neoplasms
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
CTLA-4 Antigen
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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