Association of HLA DRB1 polymorphism with susceptibility to myelodysplastic syndrome and aplastic anemia in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 296-299, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326943
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the HLA-DRB1 polymorphism with susceptibility to myelodysplastic syndrome (MDS) and aplastic anemia (AA) in Chinese Han population.</p><p><b>METHODS</b>The polymorphism of HLA-DRB1 alleles in 242 patients with MDS, 115 patients with AA and 2264 umbilical cord blood control samples were tested by polymerase chain reaction-sequence specific primer (PCR-SSP).</p><p><b>RESULTS</b>Compared with normal controls, the frequency of HLA-DRB1*15 was significantly increased in the MDS group and AA group (22.93% vs. 17.25%, Chi-square = 9.662, OR= 1.428, P= 0.003; 26.52% vs. 17.25%, Chi-square = 12.924, OR= 1.732, P= 0.001). And this is mainly due to the increase in the male patients in both patient groups in the MDS males, 24.68% vs. 17.25%, Chi-square= 11.194, OR= 1.572, P= 0.001, and in the AA males, 29.29% vs. 17.25%, Chi-square= 13.563, OR= 1.987, P= 0.001. No significant difference between the controls and the female patients in both groups was observed.</p><p><b>CONCLUSION</b>The HLA-DRB1*15 could be a susceptibility allele for MDS and AA male patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Myelodysplastic Syndromes
/
HLA-DR Antigens
/
Genetic Predisposition to Disease
/
Asian People
/
Alleles
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
/
Anemia, Aplastic
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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