Cytogenetic study of mantle cell lymphoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 283-286, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-326946
ABSTRACT
<p><b>OBJECTIVE</b>To explore the cytogenetic features of mantle cell lymphoma (MCL).</p><p><b>METHODS</b>Bone marrow cells from 18 MCL patients with bone marrow invasion were cultured for 24 hours, then routine karyotype analysis was performed with R-banding technique. Interphase fluorescence in situ hybridization (FISH) and a panel of 5 probes, including CCND1/IgH, CEP12, D13S319, p53 gene and ATM gene, were used to investigate the cytogenetic features of the samples.</p><p><b>RESULTS</b>Chromosome aberrations were found in 9 (64.3%, 9/14) patients by conventional cytogenetics (CC), 8(57.1%, 8/14) patients had the aberration of t(11; 14), 6(42.9%, 6/14) had complex aberrant karyotypes, of which 2 (14.3%, 2/14) had highly complex aberrant karyotypes. A total of 28 abnormalities were detected, among them 19 (67.9%) were structural abnormalities, the other 9 (32.1%) were numerical aberrations. The aberration of t(11; 14) was found in all 18 (100%) patients with MCL by FISH. Secondary cytogenetic aberrations were detected in 14 patients by FISH. The most common abnormality was del(11q22.3) (57.1%), the rate of aberrations for del(17p13), + 12 and del(13q14) were 42.9%, 35.7% and 21.4%, respectively. Two (14.3%) and 4 (28.6%) patients were detected to have combinations of 2 and 3 aberrations.</p><p><b>CONCLUSION</b>In addition to t(11; 14), most MCL patients have other chromosome aberrations, especially complex aberrant karyotype.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Chromosomes, Human, Pair 11
/
Chromosomes, Human, Pair 14
/
Mortality
/
Chromosome Aberrations
/
Lymphoma, Mantle-Cell
/
Genetics
/
Karyotyping
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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