Structure and degradation property of the PVA-collagen complex drug membrane / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the structure and degradation property of the polyvinyl alcohol (PVA)-collagen complex drug membrane.</p><p><b>METHODS</b>Drug collagen membrane was complexed with PVA. The physical and chemical properties of the membrane were characterized by transmission electron microscopy, scanning electron microscope, forier transform-infrared spectroscopy and differential scanning calorimetry. Degradation experiment was performed to determine the degradation property of membrane and a degradation curve was therefor drawn.</p><p><b>RESULTS</b>The thermodynamic stability of collagen membrane was not destroyed by adding PVA. Collagen had good compatibility with PVA. Compared with collagen membrane, collagen-PVA complex membrane had smaller and evener pores. Adding PVA decreased the degradation rate of membrane.</p><p><b>CONCLUSIONS</b>PVA-collagen membrane has better microstructure and antidegradation property than collagen membrane.</p>