Synthesis and the drug release properties of poly(acrylamide-co-glycosylallylamide) hydrogels / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 960-963, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-327170
ABSTRACT
Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymers
/
Pharmacokinetics
/
Chemistry
/
Aspirin
/
Acrylamide
/
Hydrogels
/
Delayed-Action Preparations
/
Gluconates
/
Lactones
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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