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Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 138-145, 2017.
Article in English | WPRIM | ID: wpr-327197
ABSTRACT
<p><b>OBJECTIVE</b>To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV).</p><p><b>METHODS</b>The antinociceptive effect of AV (400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally, the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography.</p><p><b>RESULTS</b>Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05).</p><p><b>CONCLUSIONS</b>AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLcN and taurine contribute, at least in part, to the anti-inflammatory activity of AV.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain / Pharmacology / Pain Measurement / Water / Plant Extracts / Chemistry / Isopoda / Drug Therapy / Edema / Analgesics Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain / Pharmacology / Pain Measurement / Water / Plant Extracts / Chemistry / Isopoda / Drug Therapy / Edema / Analgesics Limits: Animals Language: English Journal: Chinese journal of integrative medicine Year: 2017 Type: Article