The dynamic expression of TNF-alpha mRNA of hypertrophic scars and its roles / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 57-59, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-327323
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of tumor necrosis factor alpha TNF-alpha in the hypertrophic scar and find a valid way to treat the hypertrophic scars with gene therapy.</p><p><b>METHODS</b>TNF-alpha mRNA expression was tested with a semiquantitative reverse polymerase chain reation (RT-PCR) method in the different period of a hypertrophic scar.</p><p><b>RESULTS</b>There was a significant increase of TNF-alpha mRNA as the hypertrophic scar was getting mature (P < 0.01). However, the ratios of TNF-alpha mRNA was significantly in a lower level than the normal scar.</p><p><b>CONCLUSIONS</b>The results suggest that TNF-alpha may play an important role in normal would healing, but the hypertrophic scar may result from the shortage of the TNF-alpha. This indicates that to increase the TNF-alpha with gene therapy may be a good way to treat the hyphertrophic scar.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Gene Expression
/
Tumor Necrosis Factor-alpha
/
Cicatrix, Hypertrophic
/
Reverse Transcriptase Polymerase Chain Reaction
/
Genetics
/
Metabolism
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2004
Type:
Article
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