The effects of chitosan on different-derived fibroblasts / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 53-56, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-327324
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of chitosan on the biological activities of the fibroblasts derived from different tissues.</p><p><b>METHODS</b>The biological activities of the fibroblasts derived from different tissues were evaluated with a MTT method for fibroblast proliferation, photic and electronic microscope for morphologic and subcellular structure, 3H-proline uptake method for collagen secretion and ELISA box for the secretion of TGF-beta 1, FGF-AB, and IL-8.</p><p><b>RESULTS</b>This study showed that the chitosan inhabited the proliferation of the fibroblasts and the secretion of the TGF-beta 1, FGF-AB and collagen of the fibroblasts with a dose-depended manner in the normal skin, hypertrophic scar and keloid groups, but it stimulated the IL-8. However, there were no significant differences among the three groups (P > 0.05).</p><p><b>CONCLUSION</b>The chitosan could inhibit the growth, proliferation, biosynthesis and secretion of the fibroblasts, and it may be used to treat different scars.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Pharmacology
/
Hemostatics
/
Microscopy, Electron
/
Cell Division
/
Chitin
/
Interleukin-8
/
Transforming Growth Factor beta
/
Bodily Secretions
/
Chitosan
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2004
Type:
Article
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