Efficacy of integrative medicine for the treatment of rheumatoid arthritis and its effect on glucocorticoid receptor expression / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 1261-1264, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-327457
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and mechanism of Fengshikang (FSK) in treating rheumatoid arthritis (RA).</p><p><b>METHODS</b>Thirty-eight patients with RA of damp-heat block syndrome type in Chinese medicine (CM), were randomized into two groups. They all received glucocorticoid therapy for 1 month, but FSK was administered to the 20 patients in the CM group in addition, while to the 18 in the WM group, MTX was given. Besides, a normal control group with 20 healthy subjects was set up. Blood levels of RA related indices were measured and compared.</p><p><b>RESULTS</b>After treatment, the levels of rheumatoid factor (RF) and C-reactive protein (CRP) were significantly reduced in both groups (P<0.05), but the reduction was more significant in the CM group (P<0.05). No significant change was found in the level of ESR after treatment and showed no significant difference between groups (P>0.05). Both hGRalpha mRNA and hGRbeta mRNA expressions were significantly higher in the patients than in the normal controls (P<0.01), they were lowered after treatment in the CM group (P<0.01), but significant reduction could only be found in level of hGRbeta mRNA in the control group (P<0.01).</p><p><b>CONCLUSION</b>FSK combined with glucocorticoid can effectively control the inflammatory reaction, decrease the level of hGRalpha and hGRbeta expressions and enhance the clinical efficacy in treating RA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
RNA, Messenger
/
Methylprednisolone
/
Drugs, Chinese Herbal
/
Receptors, Glucocorticoid
/
Therapeutic Uses
/
Drug Therapy
/
Genetics
/
Glucocorticoids
/
Phytotherapy
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article
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