Hepatitis C virus genotypes in China: a systematic review / 中华流行病学杂志

ABSTRACT

Objective To provide information on the geographical distribution of hepatitis C virus (HCV) genotype and subtypes in the Chinese population.Methods A comprehensive search was carried out in CHKD (China Hospital Knowledge Database),Wanfang (Chinese),CBMDisc and PubMed databases to identify all the papers being published on HCV genotypes/serotypes and subtypes in China.All studies were grouped according to the sites,period and objects of the studies,to analyse the distribution of HCV genotype.Results A total of 140 studies were included in this Meta-analysis program,which contained 168 records.We found that the predominate genotypes in China were 1 b and 2a subtype,and the distributions of HCV subtypes were different in the western or southern parts of the country.Subtypes 3a,3b and 6a had been significantly increased along with the decrease of subtypes 1b and 2a.There were various HCV subtypes among injection drug users with subtypes 3a,3b and 6a found among them.Conclusion The distribution of HCV genotypes and subtypes in the Chinese population had changed significantly.