Impact of drug molecules on HP-β-CD compound inclusion / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2893-2899, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-327872
ABSTRACT
To study the interaction of drugs of different properties, namely puerarin, borneol and catalpol in the process of in- clusion, in order to explore the inclusion regularity of multi-component and multi-property traditional Chinese medicine compound in- clusions. With HP-β-CD as the inclusion material, the freeze-drying method was used to prepare the inclusion. The inclusion between puerarin, borneol and catalpol was tested by measuring the inclusion concentration, DSC and X-ray diffraction. According to the find- ings, when insoluble drugs puerarin and borneol were included simultaneously, and puerarin was overdosed, puerarin included was almost equal to puerarin included, and borneol was not included. When puerarin was under-dosed, and HP-β-CD was overdosed, borne- ol was included, and the simultaneous inclusion was lower than the separate inclusion of borneol. When water-soluble drug catalpol was jointly included with puerarin or borneol, the simultaneous inclusion was almost the same with their separate inclusion, without charac- teristic peak of catalpol in DSC and X-ray diffraction patterns. There is a competition in the simultaneous inclusion between water-solu- ble drugs puerarin and borneol and a stronger competition in puerarin. The water-soluble drug catalpol could be included with HP-β-CD with no impact on the inclusion of puerarin or borneol.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Camphanes
/
Brain Ischemia
/
Chemistry
/
Therapeutic Uses
/
Beta-Cyclodextrins
/
Drug Compounding
/
Drug Therapy
/
Iridoid Glucosides
/
2-Hydroxypropyl-beta-cyclodextrin
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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