Distinct effect of Wansheng Huafeng Dan containing ardisia crenata on renal transporters, mercury accumulation and Kim-1 expression from mercuric chloride / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1892-1896, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-327901
ABSTRACT
To study the effect of Wansheng Huafeng Dan (WSHFD) and mercuric chloride on renal mercury (Hg) extraction transporters (Oat1, Oct2), renal mercury excretion transporters (Mrp4, Mate2K), renal mercury accumulation and kidney injury molecule-1 (Kim-1). The ancient prescription of WSHFD containing 10-fold Hg caused much lower renal mercury accumulation and renal toxicity than HgCl2 in rats, with less effect on renal transporters than HgCl2. The above indicators had no significant difference in WSHFDO, WSHFD2 and WSHFD3 groups, indicating no effect of WSHFD with reduced or no cinnabar.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Transport
/
Drugs, Chinese Herbal
/
Cell Adhesion Molecules
/
Gene Expression
/
Chemistry
/
Rats, Sprague-Dawley
/
Multidrug Resistance-Associated Proteins
/
Ardisia
/
Genetics
/
Kidney
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS