Study on differentially expressed proteins of effect of kudiezi injection on cerebral cortexin rats with cerebral ischemic stroke and heat toxin syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1874-1879, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-327904
ABSTRACT
This study is to investigate the modulation of Kudiezi (KDZ) injection on differential protein expression in cerebral cortex of rats with cerebral ischemic stroke and heat toxin syndrome established by intraperitoneal injection of carrageenan and middle cerebral artery occlusion (MCAO) methods. According to random number table rats were divided into three groups drug group, model group and sham group. The tripheye tetrazolium chloride (TTC) staining and HE staining were used to observe brain tissue injury of rats. After therapeutic intervention with above drug for seventy-two hours, the level of differential protein expression was analyzed by two-dimensional gel electrophoresis (2-DE). The results show that there are differential protein expressions between cerebral ischemic stroke and heat toxin syndrome rats and sham rats. Furthermore, as a Chinese medicine injection with effect of clearing heat, resolving toxin and dredging collaterals, KDZ injection can decrease alleviate morphological changes of cerebral ischemia, regulate the levels of some differential proteins expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Drugs, Chinese Herbal
/
Gene Expression
/
Cerebral Cortex
/
Brain Ischemia
/
Rats, Sprague-Dawley
/
Stroke
/
Drug Therapy
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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