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Feasibility study of QAMS for quantitative analysis of multiple structural types of ingredients in Zhizi Jinhua pill / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-327912
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the technical feasibility of QAMS to determine different structural types of ingredients in Zhizi Jinhua pill, a Chinese patent medicine.</p><p><b>METHOD</b>Emodin was chosen as the internal reference substance. The relative correction factors (RCF) of berberine, baicalin, wogonoside, baicalein, aloe-emodin, wogonin, rhein, chrysophanol and physcion to emodin were calculated with the peak areas determined at 254 nm. The ruggedness of these RCFs was validated. The contents of emodin in the samples of Zhizi Jinhua pill were determined by using the external standard method, and the contents of the other nine ingredients were calculated by their RCFs. The contents of these ten ingredients in all samples were also determined by the external standard method.</p><p><b>RESULT</b>No significant differences were observed between the quantitative results of the two methods. The obtained RCFs were credible.</p><p><b>CONCLUSION</b>The established QAMS method can be used for quantitative determination of different structural types of multi-compounds in Zhizi Jinhua pill. It can provide reference for the quality control of Chinese patent medicine.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Drugs, Chinese Herbal / Chemistry / Chromatography, High Pressure Liquid / Dosage Forms / Methods Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Drugs, Chinese Herbal / Chemistry / Chromatography, High Pressure Liquid / Dosage Forms / Methods Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article