Research on expression of human papillomavirus type 16 and telomerase in oral lesions / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 119-121, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-327927
ABSTRACT
<p><b>OBJECTIVE</b>To define a correlation between human papillomavirus (HPV) type 16 and telomerase activity during the carcinogenesis of oral mucosa.</p><p><b>METHODS</b>HPV16 DNA and human telomerase reverse transcriptase (hTRT) mRNA were detected in 82 cases of paraffin embedded tissues including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 cases of oral dysplasia lesions and 38 cases of oral squamous cell carcinomas (OSCCs) by PCR and in situ hybridization (ISH) respectively.</p><p><b>RESULTS</b>HPV16DNA was positive in 14.3% (1/7) of normal oral mucosa, 42.9% (3/7) of hyperplasia lesions, 66.6% (20/30) of dysplasia lesions and 92.1% (35/38) of OSCCs. hTRTmRNA was detectable in 30.0% (9/30) of oral dysplasia lesions and 81.6% (31/35) of OSCCs while normal oral mucosa and hyperplasia lesions were negative. Expression of HPV16DNA and hTRTmRNA were co-ordinate in 67.0% (55/82) cases.</p><p><b>CONCLUSIONS</b>HPV16 infection may play an important role in carcinogenesis of oral mucosa by activation of telomerase.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Papillomaviridae
/
Pathology
/
Virology
/
DNA, Viral
/
RNA, Messenger
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Telomerase
/
DNA-Binding Proteins
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2001
Type:
Article
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