A Novel-Thalassemic Mutation, Codons 89/90-TG, Found in Two Korean Families / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 160-163, 2001.
Article
in Korean
| WPRIM
| ID: wpr-32793
ABSTRACT
We describe a novel-thalassemia mutation, the deletion of TG at codons 89/90 of the globin gene, found in two unrelated Korean families. Their hematological findings varied, but some patients showed prominent anemia. This mutation would introduce a premature stop codon (TGA) at codon 93. But a RNA study revealed that the / ratio was within normal range, and the amount of the mutant -globin RNA was comparable to that of normal-globin RNA. These data suggests this novel mutation as a dominant type. The haplotype and frameworks linked to the mutation were different between the two families.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Thalassemia
/
Haplotypes
/
Codon
/
Globins
/
RNA
/
Codon, Nonsense
/
Asian People
/
Anemia
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Clinical Pathology
Year:
2001
Type:
Article
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