Ingredients of Shuanghuanglian injection powder permeation through placental barrier of rat in pregnancy / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1626-1629, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-328125
ABSTRACT
<p><b>OBJECTIVE</b>Use HPLC to study the permeation of ingredients of Shuanghuanglian injection powder (SHL) through placental barriers of rats at different stages of pregnancy.</p><p><b>METHOD</b>The pregnant rats were administered SHL for 5 d through caudalis vena at different stages of pregnancy. Plasma and embryonic tissues were obtained 12 h after the final administration of SHL. The componds in biological specimen were identified by HPLC.</p><p><b>RESULT</b>Baicalin, luteolin and wogonoside were the main compounds in plasma. Wogonoside retained in first trimester embryonic tissues, and baicalin retained in the embryonic tissues of different pregnant stages.</p><p><b>CONCLUSION</b>Baicalin is the main compound of SHL through placental barriers of rats. Embryotoxicity of baicalin should be considered as the key point to evaluate the safety of SHL.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Placenta
/
Drugs, Chinese Herbal
/
Rats, Wistar
/
Models, Animal
/
Injections
/
Metabolism
Limits:
Animals
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS