Effect of Taohong Qinlian Decoction on HMGB1 in Septic Rat Cardiac Muscle / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 445-448, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-328283
ABSTRACT
<p><b>OBJECTIVE</b>To observe the levels of high mobility group box-1 protein (HMGB1), tumor necrosis factor-alpha (TNF-α), IL-6, troponin I (Tn I) release in septic rats, and to explore themechanism of Taohong Qinlian Decoction (TQD) in the treatment of septic myocardial injury.</p><p><b>METHODS</b>A total of 48 healthy male Wistar rats of clean grade were randomly divided into the sham-operation group (Sham), the sepsis model group (CLP), and the TQD treatment group (ZY), 16 in each group. Concen-trations of TNF-α, IL-6, Tn I, and HMGB1 expression were detected in each group at 24 and 48 h after operation. Pathological changes of cardiac muscle were observed under light microscope.</p><p><b>RESULTS</b>Concentrations of TNF-α, IL-6, Tn I and HMGB1 at 24 and 48 h after operation were significantly higher in the CLP group than in the Sham group (P < 0.01). Concentrations of TNF-α, IL-6, Tn I, and HMGB1 at 24 and 48 h after operation were significantly lower in the ZY group than in the CLP group (P < 0.05). Myocardial injury occurred in the CLP and the ZY group under light microscope. And this injury was more severe in the CLP group than in the ZY group.</p><p><b>CONCLUSION</b>TQL could reduce the level of sepsis-related inflammatory cytokines and protect myocardium in septic rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Drugs, Chinese Herbal
/
Random Allocation
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Rats, Wistar
/
Sepsis
/
Troponin I
/
HMGB1 Protein
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2016
Type:
Article
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