Influence factors of reconstitution of killer cell immunoglobulin-like receptor on NK cells following non-T-cell-depleted haploidentical hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 103-106, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-328366
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence factors of reconstitution of killer cell immunoglobulin-like receptor (KIR) on NK cells in the early stage after non-T cells depletion (non-TCD) HLA-mismatched hematopoietic stem cell transplantation (HSCT).</p><p><b>METHODS</b>The expression of KIR (CD158a, CD158b, CD158e) on NK cells from peripheral blood (PB) in 24 patients and their donors before and after HLA-mismatched non-TCD HSCT on day +30, +60, were detected by flow cytometry (FCM). Meanwhile the number of the CD3, CD4, CD8, CD14, CD34 positive cells in the allograft were also tested by FCM.</p><p><b>RESULTS</b>The high dose of CD4+ T cells in the allograft was positively correlated with increased aGVHD occurrence and inversely with the expression of CD158a, CD158aCD158b and CD158e on day +30 and +60. Furthermore, the expression of the CD158b [(19.27 +/- 9.40)% vs (28.92 +/- 10.59)%, P = 0.018 ] and CD158aCD158b [(7.30 +/- 4.73)% vs ( 14.26 +/- 9.71)%, P = 0.016] were higher in patients with 0 - I aGVHD than in patients with II - IV aGVHD.</p><p><b>CONCLUSION</b>Both of the T cells in the allograft and the occurrence of GVHD in the early stage after transplantation delayed the recovery of KIR on NK cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Homologous
/
Killer Cells, Natural
/
T-Lymphocytes
/
Hematopoietic Stem Cell Transplantation
/
Allergy and Immunology
/
Receptors, KIR
/
Graft vs Host Disease
/
HLA Antigens
/
Metabolism
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2007
Type:
Article
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