Long-term therapeutic outcome of patients with acute promyelocytic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 15-18, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-328380
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the long-term therapeutic outcome of patients with acute promyelocytic leukemia(APL).</p><p><b>METHODS</b>Newly diagnosed APL patients were treated with ATRA as induction therapy followed by 3-4 courses of combined consolidation chemotherapy and 2 year maintenance therapy with ATRA and 6-MP + methrotrexate, alternatively. Patients were regularly monitored with nested RT-PCR for PML-RARalpha fusion transcript at the end of consolidation chemotherapy and in the following 4 to 5 years.</p><p><b>RESULTS</b>A total of 81 patients with APL were entered the trial, 75 (92.6%) patients achieved CR. Early death (ED) rate was 6.6%. ED patients had significantly higher WBC count and higher percentage of peripheral promyelocyte than those achieved CR. Of 65 patients received consolidation, 60 (92.3%) were proved PML-RARalpha fusion gene negative at the end of the 3rd courses and 3 (4.6%) the end of the 4th courses of consolidation. The mean follow-up was 21.2 (8-64) months, 6 patients relapsed (relapse rate 9.2%). The 5-year Kaplan-Meier estimates of overall survival (OS) rate was (86.6 +/- 4.6)%. For 65 patients received consolidation therapy, the 5-year relapse-free survival (RFS) rate was 82.7%. COX-regression analyses showed only high WBC count (>10 x 10(9)/L) had an adverse prognostic influence on OS.</p><p><b>CONCLUSION</b>More than 80% of APL patients treated with systemic therapy could experience long-term relapse-free survival.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tretinoin
/
Remission Induction
/
Leukemia, Promyelocytic, Acute
/
Antineoplastic Combined Chemotherapy Protocols
/
Follow-Up Studies
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2007
Type:
Article
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